Journal
MACROMOLECULAR RAPID COMMUNICATIONS
Volume 26, Issue 1, Pages 23-28Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/marc.200400466
Keywords
block copolymers; N-carboxy anhydrides; peptides; poly(ethylene oxide); ring-opening polymerization
Categories
Ask authors/readers for more resources
The ring-opening polymerization of N-carboxy anhydrides (NCA) of gamma-benzyl-L-glutamate and beta-benzyl-L-aspartate was studied in the presence of an ammonium chloride-functionalized poly(ethylene oxide) macroinitiator, which possibly prevents side reactions such as NCA deprotonation. Although polymerization initiated by such macro-initiators was found to be quite slow, well-defined conjugates of poly(ethylene oxide)-block-poly(gamma-benzyl-L-glutamate) and poly(ethlene oxide)-block-poly(beta-benzyl-L-aspartate) with polydispersity indexes as low as 1.05 were prepared. Moreover, the presence of ammonium chloride chain ends significantly prevented end-group cyclization of poly(gamma-benzyl-L-glutamate) after polmerization.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available