Journal
INTERNATIONAL JOURNAL OF PHARMACEUTICS
Volume 288, Issue 1, Pages 3-10Publisher
ELSEVIER
DOI: 10.1016/j.ijpharm.2004.09.007
Keywords
particle design; supercritical fluid; dissolution enhancement; micronization; nanoparticles; microspheres
Categories
Ask authors/readers for more resources
In this first of two articles, we discuss some issues surrounding the dissolution rate enhancement of poorly-soluble active ingredients micronized into nano-particles using several supercritical fluid particle design processes including rapid expansion of supercritical solutions (RESS), supercritical anti-solvent (SAS) and particles from gas-saturated solutions/suspensions (PGSS). Experimental results confirm that dissolution rates do not only depend on the surface area and particle size of the processed powder, but are greatly affected by other physico-chemical characteristics such as crystal morphology and wettability that may reduce the benefit of micronization. (C) 2004 Elsevier B.V. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available