Journal
MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS
Volume 569, Issue 1-2, Pages 13-27Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.mrfmmm.2004.09.006
Keywords
yeast; oxidative stress; DNA; stress-activated protein kinases (SAPK); reactive oxygen species (ROS)
Funding
- NIGMS NIH HHS [GM059788, GM070405] Funding Source: Medline
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Oxidative stress that generates the reactive oxygen species (ROS) is one of the major causes of DNA damage and mutations. The DNA damage checkpoint that arrests cell cycle and repairs damaged DNA has been a focus of recent studies and the genetically amenable model systems provided by yeasts have been playing a leading role in the eukaryotic checkpoint research. However, means to eliminate ROS are likely to be as important as the DNA repair mechanisms in order to suppress mutations in the chromosomal DNA, and yeasts also serve as excellent models to understand how eukaryotes combat oxidative stress. In this article, we present an overview of the signaling pathways that sense oxidative stress and induce expression of various anti-oxidant genes in the budding yeast Saccharomyces cerevisiae, the fission yeast Schizosaccharomyes pombe and the pathogenic yeast Candida albicans. Three conserved signaling modules have been identified in the oxidative stress response of these diverse yeast species: the stress-responsive MAP kinase cascade, the multistep phosphorelay and the AP-1-like transcription factor. The structure and function of these signaling modules are discussed. (C) 2004 Elsevier B.V. All rights reserved.
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