Journal
ORGANIC LETTERS
Volume 7, Issue 1, Pages 95-98Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol047824w
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An anionic chiral auxiliary mediated asymmetric alkylation of carbamate 2 provides 3-substituted isoindolinones 4 in high ee. This methodology was used in the first asymmetric synthesis of (+)-lennoxamine.
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