Journal
CANCER LETTERS
Volume 217, Issue 1, Pages 87-95Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2004.05.021
Keywords
oral cancer; extracellular matrix; invasion; osteopontin; basaloid squamous cell carcinoma; antisense
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We examined expression and function of osteopontin (OPN) in oral cancer cell lines using antisense oligonucleotide (AS). Quantitative real-time RT-PCR showed that expression in BSC-OF cells was significantly higher (10-fold) than that in KB cell. AS-study showed that foci of AS-treated BSC-OF cells possessed thin processes and radiated morphologically, although BSC-OF cells showed round foci. Cell growth in AS-group was lower (< 80%) than the control. Invasion ability in AS-group became significantly lower (P<0.01). These results suggest that BSC-OF cell is useful for over-expression of OPN, and that OPN contributes to morphology, growth and invasion. (C) 2004 Elsevier Ireland Ltd. All rights reserved.
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