Journal
SCIENCE
Volume 307, Issue 5707, Pages 254-258Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1102901
Keywords
-
Categories
Funding
- NIAID NIH HHS [AI33856] Funding Source: Medline
- NIDDK NIH HHS [DK54427, DK33506] Funding Source: Medline
Ask authors/readers for more resources
Dendritic cells (DCs) and macrophages are critical to innate and adaptive immunity to the intestinal bacterial microbiota. Here, we identify a myeloid-derived mucosal DC in mice, which populates the entire lamina propria of the small intestine. Lamina propria DCs were found to depend on the chemokine receptor CX(3)CR1 to form transepithelial dendrites, which enable the cells to directly sample luminal antigens. CX(3)CR1 was also found to control the clearance of entero-invasive pathogens by DCs. Thus, CX(3)C1-dependent processes, which control host interactions of specialized DCs with commensal and pathogenic bacteria, may regulate immunological tolerance and inflammation.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available