Journal
CELL
Volume 120, Issue 1, Pages 111-122Publisher
CELL PRESS
DOI: 10.1016/j.cell.2004.11.014
Keywords
-
Categories
Funding
- NIGMS NIH HHS [R01 GM057043] Funding Source: Medline
Ask authors/readers for more resources
Frizzled (Fz) proteins are serpentine receptors that transduce critical cellular signals during development. Serpentine receptors usually signal to downstream effectors through an associated trimeric G protein complex. However, clear evidence for the role of trimeric G protein complexes for the Fz family of receptors has hitherto been lacking. Here, we show roles for the Go, subunit (Go) in mediating the two distinct pathways transduced by Fz receptors in Drosophila: the Writ and planar polarity pathways. Go is required for transduction of both pathways, and epistasis experiments suggest that it is an immediate transducer of Fz. While overexpression effects of the wild-type form are receptor dependent, the activated form (Go-GTP) can signal when the receptor is removed. Thus, Go is likely part of a trimeric G protein complex that directly tranduces Fz signals from the membrane to downstream components.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available