Journal
NEUROIMAGE
Volume 24, Issue 2, Pages 323-331Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.neuroimage.2004.08.042
Keywords
fMRI; functional resolution; data smoothing; motor localization; replicability; normal subjects patients
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Recent publications analyzing the influence of spatial smoothing oil fMRI brain activation results demonstrated that smoothing may artificially combine activations from adjacent though functionally and anatomically distinct brain regions and that activation from large draining vessels may be smoothed into neighboring neuronal tissue. To investigate whether functional localizations may be artificially shifted by the smoothing procedure we performed replicability measurements. Localization centers of motor hand activations achieved during different conditions (isolated hand movements and simultaneous hand and chin movements) were compared with respect to smoothing effects. The voxel with the highest probability to represent a true positive activation was localized with a non-smoothed and a standard 4 x 4 x 6 mm smoothed correlational data analysis technique. Results show an increase of motor center aberrations between measurements by about 100% due to data smoothing indicating a statistically significant decrease in localization replicability. (C) 2004 Elsevier Inc. All rights reserved.
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