Journal
COLLOIDS AND SURFACES B-BIOINTERFACES
Volume 40, Issue 1, Pages 11-18Publisher
ELSEVIER
DOI: 10.1016/j.colsurfb.2004.09.007
Keywords
liposomes; cardanol; cholesterol; Triton X-100; release of 5(6)-carboxyfluorescein; breakdown of liposomes
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Large unilamellar liposomes were prepared by hydration of 1-palmitoyl-2-oleylphosphatydilcholine (POPC) films and subsequent extrusion of the obtained liposomal suspension. Inclusion of cholesterol and cardanol brings about a stabilization of the membranes of the liposomes, as determined by their rates of release of entrapped 5(6)-carboxyfluorescein. The liposome breakdown was promoted by a non-ionic surfactant (Triton X-100) and the kinetic measurements were carried out by fluorimetry in water at 25degreesC. Morphological analyses of pant POPC liposomes in the presence and in the absence of both guests were also performed. The results obtained suggest the use of cardanol (an easy available natural product) as a replacement for cholesterol as a new possibility for stabilizing liposomes in drug targetting. (C) 2004 Elsevier B.V. All rights reserved.
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