Journal
JOURNAL OF IMMUNOLOGY
Volume 174, Issue 2, Pages 589-594Publisher
AMER ASSOC IMMUNOLOGISTS
DOI: 10.4049/jimmunol.174.2.589
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Funding
- NHLBI NIH HHS [HL58897] Funding Source: Medline
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Leukotrienes are bronchtconstrictor and vasoactive lipid mediators that are targets in the treatment of asthma. Although they are increasingly recognized to exert broad proinflammatory effects, their role in innate immune responses is Less well appreciated. These moleculees are indeed synthesized by resident and recruited leukocytes during infection. Acting via cell surface G protein-coupled receptors and subsequent intracellular signaling events, they enhance leukocyte accumulation, phagrocyte capacity for microbial ingestion and killing, and generation of other proinflammatory mediators. Interestingly, a variety of-acquired states of immunodeficiency, such as HIV infection and malnutrition, are characterized by a relative deficiency of leukotriene synthesis. The data reviewed herein point to leukotrienes as underappreciated yet highly relevant mediators of innate immunity.
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