Journal
JOURNAL OF IMMUNOLOGY
Volume 174, Issue 2, Pages 614-618Publisher
AMER ASSOC IMMUNOLOGISTS
DOI: 10.4049/jimmunol.174.2.614
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Funding
- NCI NIH HHS [CA34461] Funding Source: Medline
- NIAID NIH HHS [AI17672, AI07439] Funding Source: Medline
- NIAMS NIH HHS [AR35506] Funding Source: Medline
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Class II-restricted CD4 T cell-mediated killing of target cells has previously been documented in vitro but not in vivo. In this study, we demonstrate CD4-dependent MHC class II-restricted killing in lymphocytic choriomeningitis virus-infected mice in vivo using an in vivo cytotoxicity assay that features class II-expressing B cells as targets.
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