Journal
SCIENCE
Volume 307, Issue 5708, Pages 421-423Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1106478
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Funding
- NICHD NIH HHS [HD41609, HD36879] Funding Source: Medline
- NIGMS NIH HHS [GM64606, GM61053] Funding Source: Medline
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In contrast to most genomic DNA in mitotic cells, the promoter regions of some genes, such as the stress-inducible hsp70i gene that codes for a heat shock protein, remain uncompacted, a phenomenon called bookmarking. Here we show that hsp70i bookmarking is mediated by a transcription factor called HSF2, which binds this promoter in mitotic cells, recruits protein phosphatase 2A, and interacts with the CAP-G subunit of the condensin enzyme to promote efficient dephosphorylation and inactivation of condensin complexes in the vicinity, thereby preventing compaction at this site. Blocking HSF2-mediated bookmarking by HSF2 RNA interference decreases hsp70i induction and survival of stressed cells in the G, phase, which demonstrates the biological importance of gene bookmarking.
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