Journal
SCIENCE
Volume 307, Issue 5708, Pages 418-420Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1108177
Keywords
-
Categories
Funding
- NCRR NIH HHS [RR 17718] Funding Source: Medline
- NHLBI NIH HHS [HL 64270] Funding Source: Medline
- NIDDK NIH HHS [DK 57497, DK 54254] Funding Source: Medline
Ask authors/readers for more resources
In humans, the strong statistical association between fitness and survival suggests a link between impaired oxygen metabolism and disease. We hypothesized that artificial selection of rats based on low and high intrinsic exercise capacity would yield models that also contrast for disease risk. After 11 generations, rats with low aerobic capacity scored high on cardiovascular risk factors that constitute the metabolic syndrome. The decrease in aerobic capacity was associated with decreases in the amounts of transcription factors required for mitochondrial biogenesis and in the amounts of oxidative enzymes in skeletal muscle. Impairment of mitochondrial function may link reduced fitness to cardiovascular and metabolic disease.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available