Journal
JOURNAL OF ORGANIC CHEMISTRY
Volume 70, Issue 2, Pages 448-455Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jo048683e
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Funding
- NIGMS NIH HHS [GM58101] Funding Source: Medline
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DIAGRAM We describe our full report of the catalytic asymmetric addition of simple and functionalized dialkylzinc reagents to a broad range of saturated ketones and enones. The functionalized organozinc reagents contain esters, silyl ethers, alkyl chlorides, and alkyl bromides. In general, the resulting tertiary alcohol products are isolated with high ee's. With some substrates, yields are low as a result of the formation of aldol byproducts. Most substrates undergo additions with good yields reaching as high as 91 %.
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