4.7 Article

Selective attachment and release of a chemotherapeutic agent from the interior of a protein cage architecture

Journal

CHEMICAL COMMUNICATIONS
Volume -, Issue 4, Pages 447-449

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/b413435d

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Funding

  1. NIBIB NIH HHS [R01 EB00432] Funding Source: Medline
  2. NIGMS NIH HHS [R01 GM61340] Funding Source: Medline

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The antitumor agent doxorubicin was covalently bound and selectively released in a pH dependent manner from the interior surface of a genetically modified small heat shock protein (Hsp) cage.

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