Journal
JOURNAL OF NEUROSCIENCE METHODS
Volume 141, Issue 1, Pages 83-87Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jneumeth.2004.05.015
Keywords
eyeblink conditioning; infrared reflectance; fMRI; fiber optic
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Funding
- NIMH NIH HHS [F31 MH65085, R01 MH58912] Funding Source: Medline
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We previously described a reliable system to control the timing of multiple stimuli and to detect behavioral eyeblink responses in fMRI studies of learning in animals. Here, we report a significant advancement of the original system, which incorporates a fiber-optic probe in order to avoid the interference associated with the application of pulsed field gradients during MR imaging, particularly echo planar imaging. Eyeblink responses recorded with our fiber-optic probe and modified detection circuit demonstrate the ability of our new system to acquire behavioral data free of gradient-induced artifacts. thereby eliminating the need for low-pass filtering. This fiber optic-based system Should be applicable to both animal and human imaging experiments. (C) 2004 Elsevier B.V. All rights reserved.
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