Journal
JOURNAL OF NEUROSCIENCE METHODS
Volume 141, Issue 1, Pages 103-113Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jneumeth.2004.06.001
Keywords
neuroanatomy; neurophysiology; neurosurgery; connections; electrode array; chronic recording; auditory cortex; somatosensory cortex
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Funding
- FIC NIH HHS [R03 TW05674] Funding Source: Medline
- NIDCD NIH HHS [R01 DC04318] Funding Source: Medline
- NIMH NIH HHS [R01 MH61989] Funding Source: Medline
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In this report, a method is presented for gaining direct access to cortical areas within the lateral fissure of primates for neuroanatomical tracer injections and electrode array implantation. Compared to areas on the surface of the brain. the anatomical and physiological properties of areas within the fissure are poorly understood. Typically, access to these areas is indirectly achieved by ablating or passing through intervening areas. To enable direct experimental access, a neurosurgical technique was developed in primates whereby the banks, of the lateral fissure were retracted with sparing of the vascular network and intervening areas. In some animals, anatomical tracers were directly injected into target fields without contamination of other areas. In others. multichannel electrode arrays were implanted into target areas for chronic recording of neural activity. Since, these techniques could be adapted for exploration of areas within other sulci, the approach represents an important advance in efforts to elucidate the functional organization of the primate cerebral cortex. (C) 2004 Elsevier B.V. All rights reserved.
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