Journal
FEBS LETTERS
Volume 579, Issue 3, Pages 723-727Publisher
WILEY
DOI: 10.1016/j.febslet.2004.12.051
Keywords
budding yeast; apoptosis; caspase; autophagic death; valproate; reactive oxygen species
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Valproic acid (VPA) inhibited the growth of yeast in a dose-dependent manner with complete inhibition attained at 100 mM. When cells were exposed to 25 mM VPA, the wild-type died showing apoptotic markers, while yca1Delta deleted of YCA1 encoding yeast caspase 1 survived. On the other hand, when cells were exposed to 50 mM VPA, both the wild-type and yca1Delta died showing morphological features similar to those of the autophagic death of cdc28 which was also independent of YCA1. Thus, these results suggested that yeast cells die via YCA1-dependent apoptosis when their proliferative activity is mildly impaired. (C) 2005 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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