Journal
FEBS LETTERS
Volume 579, Issue 3, Pages 803-807Publisher
WILEY
DOI: 10.1016/j.febslet.2004.12.056
Keywords
calmodulin; receptor; parathyroid hormone type 1; receptor; G-protein coupled
Funding
- NIDDK NIH HHS [K01 DK59900-01] Funding Source: Medline
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Parathyroid hormone (PTH) hinds to its receptor (PTH1 receptor, PTH1R) and activates multiple pathways. The PTH1R, a class b GPCR, contains consensus calmodulin-binding motifs. The PTH1R cytoplasmic tail interacts with calmodulin in a calcium-dependent manner via the basic 1-5-8-14 motif. Calcium-dependent calmodulin interactions with the cytoplasmic tails of receptors for PTH 2, vasoactive intestinal peptide, pituitary adenylate cyclase activating peptide, corticotropin releasing hormone, calcitonin, and the glucagon-like peptides 1 and 2 are demonstrated. The cytoplasmic tails of the secretin receptor and the growth hormone releasing hormone receptor either interact poorly or not at all with calmodulin, respectively. Fluphenazine, a calmodulin antagonist, enhances PTH-mediated accumulation of total inositol phosphates, suggesting that calmodulin regulates signaling via phospholipase C. (C) 2005 Published by Elsevier B.V. on behalf of the Federation of European Biochemical Societies.
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