Journal
FEBS LETTERS
Volume 579, Issue 3, Pages 717-722Publisher
WILEY
DOI: 10.1016/j.febslet.2004.12.050
Keywords
uncoupling protein-2; uncoupling protein-3; cancer cachexia; free fatty acid; reactive oxygen species; interleukin-15
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Implantation of a fast growing tumour to mice (Lewis lung carcinoma) resulted in a clear cachectic state characterized by a profound muscle wasting. This was accompanied by a significant increase in both UCP2 and UCP3 gene expression in skeletal muscle and heart. Interestingly, this increase in gene expression was not linked to a rise in circulating fatty acids or in a decrease in food intake, as previously reported in other pathophysiological states. These results question the concept that hyperlipaemia is the only factor controlling UCP gene expression in different pathophysiological conditions. In addition, the present work suggests that UCPs might participate in a counter-regulatory mechanism to lower the production of ROS. (C) 2005 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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