Journal
NATURE NEUROSCIENCE
Volume 8, Issue 2, Pages 137-139Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nn1390
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Knowledge of the site of action potential initiation is essential for understanding how synaptic input is converted into neuronal output. Previous studies have shown that the lowest-threshold site for initiation of action potentials is in the axon. Here we use recordings from visualized rat cerebellar Purkinje cell axons to localize the site of initiation to a well-defined anatomical structure: the first node of Ranvier, which normally forms at the first axonal branch point.
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