4.7 Article

Organic base-mediated condensation of pyridinecarboxaldehydes to azachalcones

Journal

ADVANCED SYNTHESIS & CATALYSIS
Volume 347, Issue 2-3, Pages 235-238

Publisher

WILEY-V C H VERLAG GMBH
DOI: 10.1002/adsc.200404318

Keywords

aldol reaction; azachalcones; chemoselectivity; organic catalysis; pyridinecarboxaldehydes

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A DBU-mediated aldol condensation-dehydration sequence has been used to prepare a series of synthetically important substituted 2- and 3-azachalcones. Michael products that typically accompany this sequence with inorganic bases were not observed in this protocol of high practical value.

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