Journal
INFECTION AND IMMUNITY
Volume 73, Issue 2, Pages 1187-1190Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/IAI.73.2.1187-1190.2005
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Funding
- NIAID NIH HHS [R01 AI044102, R01 AI 44102] Funding Source: Medline
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Anaplasma phagocytophilum infection induces functional neutrophil changes. Using both Candida albicans and fluorescent-aggregate phagocytosis assays, we examined whether neutrophil and dimethyl sulfoixde-differentiated HL-60 cell infection impairs internalization. A. phagocytophilum infection significantly decreased phagocytosis compared to that of controls (P < 0.05). This further impairment of neutrophil function may promote opportunistic infections and exacerbate disease.
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