Journal
MAGNETIC RESONANCE IMAGING
Volume 23, Issue 2, Pages 153-157Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.mri.2004.11.031
Keywords
parahydrogen-induced polarization; adiabatic; field cycling; MRI; contrast agents
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The order within proton pairs in organic molecules, resulting from hydrogenation with parahydrogen, can be transferred in great part to nearby carbon 13 spins through adequate field manipulations. The molecules with hyperpolarized C-13 thus obtained can be used as new contrast agents of high efficiency in MRI. After a brief presentation of the hydrogenation process and apparatus, in relatively low magnetic field, we describe the procedure of order transfer to the C-13 spins through a sudden drop from the initial field to zero field followed by an adiabatic remagnetization. The expected final polarizations in the absence of relaxation are given for several compounds. Finally, we show an example of MR images observed in vivo on animals as an illustration of the contrast capacity of this new method. (c) 2005 Elsevier Inc. All rights reserved.
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