Journal
JOURNAL OF NEUROIMMUNOLOGY
Volume 159, Issue 1-2, Pages 106-112Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jneuroim.2004.10.008
Keywords
infection; placenta; amniotic fluid; cortex; schizophrenia; animal model
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Funding
- NIMH NIH HHS [MH60352] Funding Source: Medline
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Maternal infection during pregnancy is associated with increased risk for neurodevelopmental disorders. Polyriboinosinic-polyribocytidilic acid (poly I:C) or saline was administered to rats to model maternal infection; levels of TNFalpha, brain-derived neurotrophic factor (BDNF), and nerve growth factor (NGF) were determined by ELISA. TNFalpha was significantly increased in maternal plasma, placenta, and amniotic fluid, while it was significantly decreased in fetal liver/spleen and neonatal brain. NGF and BDNF were significantly decreased in the placenta and fetal liver/spleen. There was no change in BDNF or NGF in the fetal or neonatal brain. Changes in TNFalpha, BDNF, and NGF after maternal exposure to poly I:C represent a potential mechanism through which maternal infection increases risk for neurodevelopmental disorders. (C) 2004 Elsevier B.V. All rights reserved.
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