Journal
BEHAVIORAL NEUROSCIENCE
Volume 119, Issue 1, Pages 164-179Publisher
AMER PSYCHOLOGICAL ASSOC
DOI: 10.1037/0735-7044.119.1.164
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Funding
- NIA NIH HHS [AG19903] Funding Source: Medline
- NIMH NIH HHS [MH071095] Funding Source: Medline
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Trace fear conditioning is a hippocampus-dependent learning task that requires the association of an auditory conditioned stimulus (CS) and a shock unconditioned stimulus (US) that are separated by a 20-s trace interval. Single-neuron activity was recorded simultaneously from the dentate gyrus (DG) and CA1 of rats during unpaired pseudoconditioning and subsequent trace fear conditioning. Single neurons in DG showed a progressive increase in learning-related activity to the CS and US across trace fear conditioning. Single neurons in CA1 showed an early increase in responding to the CS, which developed into a decrease in firing later in trace conditioning. Correlation analyses showed that DG and CA1 units exhibit inverse patterns of responding to the CS during trace fear conditioning.
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