Journal
RESEARCH IN NURSING & HEALTH
Volume 28, Issue 1, Pages 48-55Publisher
WILEY
DOI: 10.1002/nur.20052
Keywords
colon-26 adenocarcinoma; cancer cachexia; mice; tumor necrosis factor; conjugated linoleic acid
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Cancer cachexia is a syndrome of weight loss, muscle wasting, fatigue, and anorexia that occurs in Patients with advanced or recurrent sol id tumor disease. Tumor necrosis factor-alpha (TNFalpha) and prostaglandin E2 (PGE2) have been implicated in the biology of cachexia and serve as possible targets for treatment of this condition. Conjugated linoleic acid (CLA) is a polyunsaturated fatty acid that alters the synthesis of PGE2 and reduces the negative effects of TNF on body weight of healthy mice. We hypothesized that a diet supplemented with .5% CLA might reduce muscle wasting in mice bearing the colon-26 adenocarcinoma, an animal model of cancer cachexia. CLA preserved gastrocnemius muscle mass and reduced TNF receptors in muscle of tumor-bearing mice. These data suggest that CLA may preserve muscle mass by reducing the catabolic effects of TNF on skeletal muscle. (C) 2004 Wiley Periodicals, Inc.
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