Journal
CLINICAL BIOCHEMISTRY
Volume 38, Issue 2, Pages 116-122Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.clinbiochem.2004.10.004
Keywords
QTc; CVD; Hawaii
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Funding
- NCRR NIH HHS [G12RR03061] Funding Source: Medline
- NINDS NIH HHS [1-S11 NS043364-02] Funding Source: Medline
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Background: Few studies have examined the biochemical risk factors for prolonged QTc, a predictor of mortality in numerous studies. We report on the prevalence and risk factors for prolonged QTc in a multiethnic population in rural Hawaii. Methods: Electrocardiograms were collected from 1415 participants in a cross-sectional survey. The QT interval lengths were corrected for heart rate using Bazett's formula. Linear and logistic regression models were used to examine associations between various cardiovascular risk factors with QTc. Results: Among the CVD risk factors examined, only age, gender, 2-h glucose, and systolic blood pressure (SBP) were independently associated with QTc interval length. Significant ethnic differences in prevalence were also observed, which persisted after controlling for other risk factors. Conclusions: Significant associations between prolonged QTc and ethnic ancestry, but not cholesterol or triglyceride levels, suggest that genetic factors may play a more important role in determining QTc interval length than conventional biochemical and metabolic CVD risk factors. (C) 2004 The Canadian Society of Clinical Chemists. All rights reserved.
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