Journal
BREAST
Volume 14, Issue 1, Pages 71-74Publisher
CHURCHILL LIVINGSTONE
DOI: 10.1016/j.breast.2004.04.005
Keywords
secretory carcinoma; ETV6-NTRK3 gene fusion; male breast cancer
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Secretory carcinomas of the breast were first described as juvenile carcinoma by McDivitt and Stewart in a cohort of children. This term has been replaced by the term secretory breast carcinoma, because the entity can occur at any time of life. Carcinoma of the mate breast is uncommon and accounts for approximately 1% of all cancers in men. Recently, it has been reported that human secretory breast carcinoma expresses the ETV6-NTRK3 gene fusion that was previously cloned in pediatric mesenchymal cancers. We present the case of a 46-year-old male-to-female transsexual in whom a secretory breast carcinoma was an incidental finding. As confirmation of the histopathotogical diagnosis we detected the novel ETV6-NTRK3 gene fusion in this tumor. (C) 2004 Published by Elsevier Ltd.
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