Journal
CURRENT OPINION IN CELL BIOLOGY
Volume 17, Issue 1, Pages 3-8Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.ceb.2004.12.008
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Funding
- NICHD NIH HHS [R01HD046236] Funding Source: Medline
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In the few short years since its discovery, RNA interference (RNAi) has revolutionized the functional analysis of genomes: both technical and conceptual approaches to the investigation of gene function are being transformed as a result of this new technology. Genome-scale RNAi analyses have already been performed in the model organisms Caenorhabditis elegans (in vivo) and Drosophila melanogaster (in cell lines), ushering in a new era of RNAi-based approaches to probing the inner workings of the cell. The transformation of complex phenotypic data into mineable 'digitized' formats is fostering the emergence of a new area of bioinformatics related to the phenome.
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