Journal
PHYSIOLOGY
Volume 20, Issue -, Pages 43-53Publisher
AMER PHYSIOLOGICAL SOC
DOI: 10.1152/physiol.00040.2004
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- NHLBI NIH HHS [HL-71958] Funding Source: Medline
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The endothelium at the interface between blood and tissue acts as a primary transducer of local hemodynamic forces into signals that maintain physiological function or initiate pathological processes in vessel walls. Rapid intracellular spatial gradients of structural dynamics and signaling molecule activity suggest that mechanical cues at the molecular level guide cellular mechanotransduction and adaptation to shear stress profiles.
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