Journal
CURRENT OPINION IN PHARMACOLOGY
Volume 5, Issue 1, Pages 107-118Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.coph.2004.08.013
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Pharmacological agents have shown limited efficacy and consistency in the treatment of drug addiction. Hence, the development of new medications with improved long-term efficacy and reduced side effects should be given a high priority given the costs to society associated with drug abuse and drug-related pathologies. Neurochemical systems can be significantly altered by repeated exposure to drugs of abuse. These long-term molecular and neurochemical changes might, in turn, explain the core features of addiction - the compulsive seeking and taking of the drug - as well as the risk of relapse.
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