Journal
JOURNAL OF HYPERTENSION
Volume 23, Issue 2, Pages 247-250Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/00004872-200502000-00002
Keywords
arteries; myogenic tone; structure
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Hypertension is known to be associated with an increase in the wall/lumen ratio (W/L) of the resistance arteries. Growth, eutrophic remodelling and changes in arterial distensibility can all contribute to an increase W/L. Wall stress may stimulate growth, whereas remodelling and/or reduced distensibility may be the result of prolonged contraction. Impaired or overwhelmed pressure-induced myogenic constriction, causing increased wall stress, may explain the small artery growth seen in diabetes and secondary hypertension, respectively. We find that small artery growth is a greater predictor of cardiovascular events than an increased W/L. (C) 2005 Lippincott Williams Wilkins.
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