Journal
CURRENT OPINION IN CELL BIOLOGY
Volume 17, Issue 1, Pages 35-46Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.ceb.2004.12.009
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- NCRR NIH HHS [P41 RR011823] Funding Source: Medline
- NIGMS NIH HHS [R01 GM074215] Funding Source: Medline
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The kinetochore is a proteinaceous structure that assembles onto centromeric DNA and mediates chromosome attachment to microtubules during mitosis. This description is deceivingly simple: recent proteomic studies suggest that the diminutive kinetochores of Saccharomyces cerevisiae are comprised of at least 60 proteins organized into as many as 14 different subcomplexes. Many of these proteins, such as the centromeric histone variant CENP-A, and entire subcomplexes, such as the Ndc80(Hec1) complex, are conserved from yeast to humans despite the diverse nature of the DNA sequences on which they assemble. There have recently been advances in our understanding of the molecular basis of how kinetochores establish dynamic attachments to spindle microtubules, and how these attachments are correctly oriented to ensure segregation of sister chromatids to daughter cells.
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