Journal
BIOMATERIALS
Volume 26, Issue 5, Pages 509-517Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.biomaterials.2004.02.061
Keywords
hydroxyapatite (HA); zirconia-alumina (ZA); nano-composite in vitro; alkaline phosphatase
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The biocompatibility of zirconia-alumina (ZA) nano-composites in load-bearing applications Such as dental/orthopedic implants was significantly enhanced by the addition of bioactive HA. The ZA matrix was composed of nano-composite powder obtained front the Pechini process and had higher flexural strength than conventionally mixed zirconia-alumina composite. Because the ZA-nano-composite powder effectively decreased the contact area between HA and zirconia for their reaction during the sintering process. the HA-added ZA nano-composites contained biphasic calcium phosphates (BCP) of HA/TCP and had higher flexural strength than conventionally mixed ZA-HA composite. From the in vitro test with osteoblastic cell-lines, the proliferation and the differentiation (as expressed by the alkaline phosphatase activity) of the cellular response on the HA-added ZA nano-composites gradually increased as the amount of HA added increased. From the mechanical and biological evaluations of the HA-added ZA nano-composites, 30 HA (30 vol% HA + 70 vol% ZA) was found to be the optimal composition for load-bearing biological applications. (C) 2004 Elsevier Ltd. All rights reserved.
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