Journal
JOURNAL OF BONE AND MINERAL RESEARCH
Volume 20, Issue 2, Pages 330-340Publisher
WILEY
DOI: 10.1359/JBMR.041013
Keywords
integrins; bone morphogenetic protein-2; osteoblasts; proliferation; differentiation
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Funding
- NIAMS NIH HHS [AR32087, AR07033] Funding Source: Medline
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Both integrins and BMP-2 exert similar effects on osteoblasts. We examined the relationship between the alphav-containing integrins (alphavbeta) and BMP-2 in osteoblast function. BMP-2 stimulates alphavbeta expression. BMP-2 receptors co-localize/overlap with alphavbeta integrins, and the intact function of alphavbeta is essential in BMP-2 activity.
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