Journal
BIOPHYSICAL JOURNAL
Volume 88, Issue 2, Pages 1018-1029Publisher
CELL PRESS
DOI: 10.1529/biophysj.104.052043
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Funding
- NIGMS NIH HHS [R01 GM062342, GM 62342, GM41747] Funding Source: Medline
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Intracellular tetraethylammonium (TEA) inhibition was studied at the single-channel level in the KcsA potassium channel reconstituted in planar lipid bilayers. TEA acts as a fast blocker (resulting in decreased current amplitude) with an affinity in the 75 mM range even at high bandwidth. Studies over a wide voltage range reveal that TEA block has a complex voltage-dependence that also depends on the ionic conditions. These observations are examined in the context of permeation models to extend our understanding of the coupling between permeant ions and TEA blockade.
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