Journal
CLINICAL BIOCHEMISTRY
Volume 38, Issue 2, Pages 103-115Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.clinbiochem.2004.09.007
Keywords
non-enzymatic glycation products; Amadori product; advanced glycation end-products (AGE); diabetes; renal failure; chronic complications
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Non-enzymatic glycation products are a complex and heterogeneous group of compounds which accumulate in plasma and tissues in diabetes and renal failure. There is emerging evidence that these Compounds may play a role in the pathogenesis of chronic complications associated with diabetes and renal failure. So measurement of the products of non-enzymatic glycation has a twofold meaning: on one hand, measurement of early glycation products can estimate the extent of exposure to glucose and the subject's previous metabolic control; on the other hand, measurement of intermediate and late products of the glycation reaction is a precious instrument in verifying the relationship between glycation products and tissue modifications. This review Summarizes current knowledge about the diagnostic utility of measuring non-enzymatic glycation products. (C) 2004 The Canadian Society of Clinical Chemists. All rights reserved.
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