Journal
JOURNAL OF CELLULAR BIOCHEMISTRY
Volume 94, Issue 2, Pages 298-306Publisher
WILEY
DOI: 10.1002/jcb.20355
Keywords
DNA damage; replication interference; cell cycle checkpoints; cell cycle arrest; genomic instability; DNA damage recognition
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Funding
- NCI NIH HHS [CA76172, CA91029] Funding Source: Medline
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The DNA damage and replication checkpoints are signaling mechanisms that regulate and coordinate cellular responses to genotoxic conditions. Unlike typical signal transduction mechanisms that respond to one or a few stimuli, checkpoints can be activated by a broad spectrum of extrinsically or intrinsically derived DNA damage or replication interference. Recent investigations have shed light on how the damage and replication checkpoints are able to respond to such diverse stimuli. The activation of checkpoints not only attenuates cell cycle progression but also facilitates DNA repair and recovery of faltered replication forks,thereby preventing DNA lesions from being converted to inheritable mutations. Recently, more checkpoint targets from the cell cycle and DNA replication apparatus have been identified, revealing the increasing complexity of the checkpoint control of the cell cycle. In this article, we discuss current models of the DNA damage and replication checkpoints and highlight recent advances in the field. J. Cell. Biochem. (C) 2004 Wiley-Liss, Inc.
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