Journal
BIOMATERIALS
Volume 26, Issue 5, Pages 563-570Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.biomaterials.2004.02.068
Keywords
osteoblast; bone tissue engineering; interface; Langmuir-Blodgett lithography; nanoimprinting; nanotopography
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Topographically patterned surfaces are known to influence cellular behavior in a controllable manner. However, the relatively large surface areas (several cm 2) required for many biomaterial applications are beyond the practical limits of traditional lithography. Langmuir-Blodgett lithography, a recently developed method, was used to fabricate regularly spaced grooves of different depths (50 and 150 nm) with a periodicity of 500 nm over several square centimeter on silicon surfaces. These topographies were transferred into polystyrene surfaces by means of nanoimprinting. Primary osteoblasts were cultured on the patterned polymer surfaces. They were observed to align, elongate and migrate parallel to the grooves. The combination of Langmuir-Blodgett lithography with nanoimprinting enables the fabrication of large, nanostructured surface areas on a wide spectrum of different biomaterials. Osteoblasts show a significant anisotropic behavior to these surfaces, which can enhance cell settlement oil the surface or be used to direct tissue generation on the biomaterial interface. (C) 2004 Elsevier Ltd. All rights reserved.
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