Journal
JOURNAL OF INORGANIC BIOCHEMISTRY
Volume 99, Issue 2, Pages 530-537Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jinorgbio.2004.10.030
Keywords
ruthenium complexes; DNA binding; photocleavage
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A novel asymmetric bidentate ruthenium (II) complex, [Ru(bpy)(2)(PYNI)](2+) (bpy = 2,2'-bipyridine, PYNI = 2-(2'-pyridyl)naphthoimidazole), has been synthesized and characterized by elemental analysis, ES-MS (electrospray mass spectra) and H-1 NMR. The electrochemical behaviors of this complex were studied by cyclic voltammetry. DNA interaction studies suggest that [Ru(bpy)(2)(PYNI)](2+) binds to calf thymus DNA (CT-DNA) in an intercalative mode. Interestingly, this new Ru(II) complex has also been found to promote cleavage of plasmid pBR 322 DNA from the supercoiled form I to the open circular form II upon irradiation. (C) 2004 Elsevier Inc. All rights reserved.
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