Journal
PATHOLOGE
Volume 26, Issue 1, Pages 12-17Publisher
SPRINGER HEIDELBERG
DOI: 10.1007/s00292-004-0735-0
Keywords
pancreatic carcinoma; morphology; precursor lesions; undifferentiated pleomorphic carcinoma; progression model
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Pancreatic ductal adenocarcinoma is the most frequent malignant pancreatic tumor. It is one of the tumors that has a particularly poor prognosis. Its morphological characteristics are: preferential localization in the head of the pancreas, ductal-glandular tumor structures combined with marked desmoplasia and CEA and MUC1 positivity. Variants of this carcinoma include adenosquamous carcinomas, undifferentiated pleomorphic carcinomas and mixed ductal-endocrine tumors. With the definition of ductal lesions as pancreatic intraepithelial neoplasia, a progression model for pancreatic ductal carcinoma has been developed and corresponding gene alterations have been detected.
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