Journal
JOURNAL OF VIROLOGY
Volume 79, Issue 4, Pages 2626-2630Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/JVI.79.4.2626-2630.2005
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Funding
- NCRR NIH HHS [P51-RR00163, P51 RR000163] Funding Source: Medline
- NHLBI NIH HHS [R01-HL61928-S1] Funding Source: Medline
- NIA NIH HHS [AG20719, R01 AG020719] Funding Source: Medline
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Expression of Kaposi's sarcoma-associated herpesvirus (KSHV) lytic genes is thought to be essential for the establishment and progression of KSHV-induced diseases. The inefficiency of lytic reactivation in various in vitro systems hampers the study of lytic genes in the context of whole virus. We report here increased expression of KSHV lytic genes and increased release of progeny virus when synchronized cultures of body cavity-based lymphoma-1 cells are treated with a phorbol ester during S phase of the cell cycle.
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