Journal
EUKARYOTIC CELL
Volume 4, Issue 2, Pages 487-489Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/EC.4.2.487-489.2005
Keywords
-
Categories
Funding
- NIAID NIH HHS [R01 AI050184, R01 AI051209, R01-AI50184, R01-AI051209] Funding Source: Medline
Ask authors/readers for more resources
Thioredoxin reductase (TRR1) is an important component of the thioredoxin oxidative stress resistance pathway. Here we show that it is induced during oxidative and nitrosative stress and is preferentially localized to the mitochondria in Cryptococcus neoformans. The C neoformans TRR1 gene encodes the low-molecular-weight isoform of the thioredoxin reductase enzyme, which shares little homology with that of its mammalian host. By replacing the endogenous TRR1 promoter with an inducible copper transporter promoter, we showed that Trr1 appears to be essential for viability of this pathogenic fungus, making it a potential antifungal target.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available