Journal
JOURNAL OF INORGANIC BIOCHEMISTRY
Volume 99, Issue 2, Pages 584-588Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jinorgbio.2004.11.013
Keywords
catechins; polyphenols; Mn complexes; NMR; nuclear spin relaxation
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Metal-binding sites in epigallocatechin gallate (egcg) were identified by measuring H-1 nuclear spin relaxation time T, under the coexistence of paramagnetic Mn2+. The T-1 of the proton of gallate ring (D-ring) was shortened by the paramagnetic ion to a greater extent than the proton in gallocatechin ring (B-ring); the D-ring OH groups occupy the first coordination sphere around a metal ion to form a diolate chelate ring, while B-ring OH groups have a weak interaction with the metal ion. Comparison of changes in T-1 of egcg and epigallocatechin (egc) indicates that the gallate ring has a higher coordination capability than that of the gallocatechin ring so that the former plays a predominant role in the complex formation of egcg. (C) 2004 Elsevier Inc. All rights reserved.
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