Journal
CHEMICAL & PHARMACEUTICAL BULLETIN
Volume 53, Issue 2, Pages 229-231Publisher
PHARMACEUTICAL SOC JAPAN
DOI: 10.1248/cpb.53.229
Keywords
Bursera graveolens; 4 alpha-aryltetralin-type lignan; burseranin; picropolygamain; cytotoxic activity; Burseraceae
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A new 4alpha-aryltetralin-type lignan called burseranin (1) and a known analogous lignan picropolygamain (2) were isolated along with known triterpenes, lupeol and epi-lupeol from the methanol extract of stems of Bursera graveolens, which showed a remarkable inhibitory activity against human HT1080 fibrosarcoma cells. The whole structure of 1 was established based on combined spectral studies and the absolute structure for 2 was first confirmed by CD spectral evidence. In addition, cytotoxic activities of the stem (methanol) extract and its components are evaluated in this paper.
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