Journal
GENETICA
Volume 123, Issue 1-2, Pages 3-13Publisher
SPRINGER
DOI: 10.1007/s10709-004-2702-3
Keywords
adaptation; adaptive landscape; experimental evolution; Fisher's model; mutational landscape; QTL analysis
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Funding
- PHS HHS [2R01 G51932-06A1] Funding Source: Medline
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Theoretical work on adaptation has lagged behind experimental. But two classes of adaptation model have been partly explored. One is phenotypic and the other DNA sequence based. I briefly consider an example of each - Fisher's geometric model and Gillespie's mutational landscape model, respectively - reviewing recent results. Despite their fundamental differences, these models give rise to several strikingly similar results. I consider possible reasons for this congruence. I also emphasize what predictions do and, as important, do not follow from these models.
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