Journal
LEUKEMIA RESEARCH
Volume 29, Issue 2, Pages 135-140Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.leukres.2004.06.003
Keywords
myeloma; T cell; Th1; Th2; immunoglobulin
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To determine the clinical significance of the T helper 1 (Th1)/T helper 2 (Th2) ratio in multiple myeloma, the intracellular IFN-gamma and IL-4 were analyzed by flow cytometry in 56 patients with Multiple myeloma. The mean Th1/Th2 ratio of cases in the initial diagnosis phase and the refractory phase were higher than that of the control group. The mean serum beta-2-microglobulin in the high Th1/Th2 subgroup was significantly higher than that in the normal Th1/Th2 subgroup (P < 0.05). In conclusion, the Th1/Th2 ratio was closely related to the disease status of multiple myeloma. (C) 2004 Elsevier Ltd. All rights reserved.
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