Journal
AMERICAN JOURNAL OF MEDICAL GENETICS PART A
Volume 132A, Issue 4, Pages 365-368Publisher
WILEY
DOI: 10.1002/ajmg.a.30354
Keywords
abruptio placentae; placental abruption; MTHFD1; MTHFR; C1 synthase; folate
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This study examined the relationship between folate/homocysteine-related genetic polymorphisms: MTHFD1 1958G-->A (R653Q), MTHFR 677C-->T (A222V), MTHFR 1298A-->C (E429A), and risk of severe abruptio placentae. We genotyped 62 women with a pregnancy history complicated by severe abruptio placentae and 184 control pregnancies. Analysis of the MTHFD1 1958G-->A (R653Q) polymorphism, showed increased frequency of the 'QQ' homozygote genotype in pregnancies affected by severe abruptio placentae compared to control pregnancies (odds ratio 2.85 (1.47-5.53), P = 0.002). In contrast to previous reports, the MTHFR polymorphisms 677C-->T (A222V) and 1298A-->C (E429A) were not associated with abruptio placentae risk in our cohort, when analyzed either independently or in combination. We conclude that women who are 'QQ' homozygote for the MTHFD1 1258G-->A (R653Q) polymorphism are almost three times more likely to develop severe abruptio placentae during their pregnancy than women who are 'RQ' or 'RR.' Published 2005 Wiley-Liss, Inc.(dagger).
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