Journal
JOURNAL OF CRANIO-MAXILLOFACIAL SURGERY
Volume 33, Issue 1, Pages 50-54Publisher
CHURCHILL LIVINGSTONE
DOI: 10.1016/j.jcms.2004.05.011
Keywords
tissue engineering; injectable bone; chitosan; alginate; mesenchymal stem cells; bone morphogenetic proteins
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Aim: Several injectable materials have been used as osteogenic bone substitutes. However, none has gained universal acceptance. This study was performed to investigate whether or not chitosan-alginate gel/mesenchymal stem cells/bone morphogenetic protein-2 composites are potentially injectable materials for new bone formation. Material and methods: The composites were injected into the subcutaneous space on the dorsum of nude mice to investigate new bone tissue formation. The composites were examined histologically over a 12-week period. Results: The composites injected into the mouse were able to stimulate new bone formation, which was trabecular in type. Conclusions: This study showed that chitosan-alginate gel/MSCs/BMP-2 composites could become clinically useful injectable materials to generate new bone. (C) 2004 European Association for Cranio-Maxillofacial Surgery.
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